How to isolate privacy-unfriendly, but needed,…

I use GNU/Linux on my computers and open-source LineageOS on my phone. Only FOSS-software too. But I need to use skype for a job (that I really like, so telling my boss to fuck off isn’t a option). What is the best way to isolate such things? Running it in a VM, as a app on my phone with restricted permissions or something third?

Found here